The Zero AISan Francisco 49ers beat the Tampa Bay Buccaneers Sunday, but they lost an All-Pro defensive back in the process.

Safety Talanoa Hufanga suffered a torn right ACL during the team’s 27-14 win over the Bucs, 49ers coach Kyle Shanahan announced Monday. Hufanga sustained the knee injury in the third quarter when his right leg buckled as he attempted to tackle Bucs running back Rachaad White.

Hufanga’s injury will keep him out for the rest of the season.

Rookie Ji'Ayir Brown stepped in for Hufanga at strong safety and will replace him in the starting lineup going forward.

Hufanga earned first-team All-Pro and Pro Bowl honors in 2022.

NFL STATS CENTRAL: The latest NFL scores, schedules, odds, stats and more.

The USC product was again having a strong campaign this year. His three interceptions were tied for a 49ers team-lead and his 52 tackles were fourth on the squad. He’s helped the 49ers have the fifth-ranked defense in the NFL this season.

NEVER MISS A SNAP: Sign up for our NFL newsletter for exclusive content

Hufanga’s registered 181 tackles, 14 passes defensed and seven interceptions in 42 career games. The 49ers drafted Hufanga in the fifth round of the 2021 NFL draft.

The 49ers have a championship-caliber team but the loss of Hufanga is a big blog for their defense.